association of ccl2 c-2518t gene polymorphism with age-related macular degeneration (amd) disease in northeast of iran

purpose: to investigate the effect of ccl2c-2512t polymorphism on age-related macular degeneration (amd). methods: this study enrolled 48 patients originating from northeast of iran who suffered from dry type amd. the association of c-2518t in the promoter region of ccl2 gene was investigated using polymerase chain reaction (pcr) and restriction fragment length polymorphism (rflp). control group consisted of 69 healthy people and were matched for age, sex and ethnicity. results: statistical analysis showed a significant association of tt genotype in this polymorphism with susceptibility to amd (p=0.008). this genotype was more frequent in patients compared to the controls (60.41% vs 43.48%). conclusion: tt genotype of c-2518t gene polymorphism is associated with dry age-related macular degeneration in patients from northeast of iran.